Cirrhosis is the common result of all kinds of liver diseases developing to the end stage. It is easy to be accompanied with ascites, gastrointestinal bleeding, hepatic encephalopathy, spontaneous peritonitis and other complications. The 5-year survival rate of patient is low and the quality of life is poor. The Department of Hepatology of Beijing Hospital of Traditional Chinese Medicine has been guided by scientific research and innovation for many years, aiming to improve the clinical effect. On the basis of inheriting and developing the academic thoughts and clinical experiences of Guan Youbo and Wang Hongshi and other TCM National-level maters, we have undertaken many national and provincial key scientific research projects in the Sixth Five-Year Plan, Seventh Five-Year Plan and Eighth Five-Year Plan. We summed up effective treatment plan combining traditional Chinese medicine (TCM) with western medicine towards cirrhosis and its complications, established the therapeutic principle of "reinforcing healthy qi and removing blood stasis, regulating qi and blood". On the basis of long-term treatment towards the cause of the disease, we determine syndrome differentiation of Chinese materia medica, fully play the advantages of TCM Materia Medica, so that the disease progressing of many patients with cirrhosis was delayed, and the quality of life was improved. Some patients' cirrhosis symptom was effectively reversed.